Fowler's Solution as Understood in 1907

Uses of Fowler's Solution in 1907
Uses.—This solution has the general action of the arsenical preparations on the animal economy, already described under the head of Arseni Trioxidum. Its liquid form makes it convenient for exhibition and gradual increase, and it is the preparation generally resorted to when arsenic is given internally. It has been much employed in intermittent fever. In chorea it is almost a specific, and in nervous diseases of debility it is often very useful. In malarial affections and chorea it should be administered in ascending doses until the puffiness about the eyes or disturbance of the bowels betrays the arsenical impression. Fowler's solution is a very valuable remedy in various skin diseases, and has the great advantage over the solid preparations that the dose may be readily in-creased from day to day. One hundred minims of the solution contain the equivalent of very nearly one grain of arsenic trioxide. For the peculiar effects upon the human organism, see Arseni Trioxidum.

Duflos's antidote to the poisonous effects of Fowler's solution, and of the salts of the acids of arsenic generally, is ferric acetate with excess of base, made by dissolving freshly precipitated ferric hydroxide in acetic acid to saturation, adding an equal quantity of the hydroxide to the solution, and diluting the whole with water to the consistence of cream. If the official solution of ferric acetate be used in an emergency, the free acid should first be neutralized with a little ammonia.

Dose, of potassium arsenite solution, three to five minims (0.2 to 0.3 Co.).

This information was taken from....
The Dispensatory Of The United States Of America
By Dr. Geo. B.Wood And Dr. Franklin Bache.
Nineteenth Edition.
Thoroughly Revised, Largely Rewritten, And Based Upon The Eighth Decennial Revision Of The United States Pharmacopoeia Issued June 1, 1907.
Philadelphia And London
J.B. Lippincott Company