Fowler's Solution as Understood in 1940

Fowler's Solution Historical Information from 1940

Uses.—This solution has the general action of the arsenical preparations on the animal economy, already described under the head of Arseni Trioxidum. Its liquid form makes it convenient for gradually increasing the dose, and it is the preparation generally resorted to when arsenic is given internally. In malarial affections and chorea it should be administered in ascending doses until the puffiness about the eyes or disturbance of the bowels betrays the arsenical impression.

"Assay.—Measure exactly 20 cc. of Solution of Potassium Arsenite, dilute with 75 cc. of dis-tilled water, acidify the mixture very slightly with diluted hydrochloric acid, then dissolve in the solution 2 Gm. of sodium bicarbonate, and titrate the resulting liquid with tenth-normal iodine, using starch T.S. as the indicator. Each cc. of tenth-normal iodine is equivalent to 0.004946 Gm. of As2O3.

Dose, three to five minims (0.2-0.3 cc.), which may be gradually increased.
Storage.—Preserve "in tight containers."

This information was taken from....
Wood - Osol United States Dispensatory 23rd Edition 1943